LKB1 regulates germinal center formation and termination.
نویسندگان
چکیده
LKB1 regulates germinal center formation and termination Lynnea R Waters, Nicole C Walsh & Michael A Teitell a Molecular Biology Institute; University of California at Los Angeles; Los Angeles, CA USA b Department of Pathology and Laboratory Medicine; University of California at Los Angeles; Los Angeles, CA USA c Broad Stem Cell Research Center; Department of Pediatrics and Bioengineering; California NanoSystems Institute; University of California at Los Angeles; Los Angeles, CA USA d Jonsson Comprehensive Cancer Center; University of California at Los Angeles; Los Angeles, CA USA Accepted author version posted online: 01 Jun 2015.Published online: 01 Jun 2015.
منابع مشابه
LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.
T-cell-dependent antigenic stimulation drives the differentiation of B cells into antibody-secreting plasma cells and memory B cells, but how B cells regulate this process is unclear. We show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers (GCs). Lkb1-deficient B cells (BKO) undergo spontaneous B-cell activation and secretion ...
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ورودعنوان ژورنال:
- Cell cycle
دوره 14 14 شماره
صفحات -
تاریخ انتشار 2015